Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs

@article{Chowdhury2008DynamicCC,
  title={Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs},
  author={Tina T Chowdhury and Shah Arghandawi and June Brand and O. O. Akanji and Dan L. Bader and Donald Salter and David A Lee},
  journal={Arthritis Research & Therapy},
  year={2008},
  volume={10},
  pages={R35 - R35}
}
BACKGROUND Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenase (COX)-2 enzymes. To identify the specific interactions that are activated by both types of stimuli, we examined the effects of dynamic compression on levels of expression of… CONTINUE READING