Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin.

@article{Shih1999DynamicCO,
  title={Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin.},
  author={M Shih and Feng Lin and John D Scott and H y Wang and Craig C. Malbon},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 3},
  pages={1588-95}
}
Signals mediated by G-protein-linked receptors display agonist-induced attenuation and recovery involving both protein kinases and phosphatases. The role of protein kinases and phosphatases in agonist-induced attenuation and recovery of beta-adrenergic receptors was explored by two complementary approaches, antisense RNA suppression and co-immunoprecipitation of target elements. Protein phosphatases 2A and 2B are associated with the unstimulated receptor, the latter displaying a transient… CONTINUE READING

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