Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories.

@article{Hess2007DynamicCD,
  title={Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories.},
  author={Samuel T. Hess and Travis J. Gould and Manasa V. Gudheti and Sarah A. Maas and Kevin D. Mills and Joshua Zimmerberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 44},
  pages={17370-5}
}
Organization in biological membranes spans many orders of magnitude in length scale, but limited resolution in far-field light microscopy has impeded distinction between numerous biomembrane models. One canonical example of a heterogeneously distributed membrane protein is hemagglutinin (HA) from influenza virus, which is associated with controversial cholesterol-rich lipid rafts. Using fluorescence photoactivation localization microscopy, we are able to image distributions of tens of thousands… CONTINUE READING

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