Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus

  title={Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus},
  author={Pierre Martinez and Margriet R. Timmer and Chiu T. Lau and Silvia Calpe and Maria Del Carmen Sancho-Serra and Danielle Straub and A M Baker and Sybren L. Meijer and Fiebo J. W. ten Kate and Rosalie Ch Mallant-Hent and Anton H J Naber and Arnoud H. A. M. van Oijen and Lubbertus C. Baak and Pieter Scholten and Clarisse J M B{\"o}hmer and Paul A Fockens and Jacques J. Bergman and Carlo C. Maley and Trevor A Graham and Kausilia K Krishnadath},
  booktitle={Nature communications},
Surveillance of Barrett's oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median interval of 37 months in 195 non-dysplastic Barrett's patients, and a third time point in a subset of 90 patients at a median interval of 36 months, to study clonal evolution at single-cell resolution. Baseline genetic diversity predicts progression and remains… CONTINUE READING
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