Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency

@article{Hawkins2011DynamicCS,
  title={Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency},
  author={R. David Hawkins and Gary Chung Hon and Chuhu Yang and Jessica E. Antosiewicz-Bourget and Leonard K. Lee and Que-Minh Ngo and Sarit A. Klugman and Keith A. Ching and Lee E. Edsall and Zhen Ye and S. N. Kuan and Pengzhi Yu and Hui Liu and Xinmin Zhang and R. D. Green and Victor V. Lobanenkov and Ron Stewart and James A. Thomson and Bing Ren},
  journal={Cell Research},
  year={2011},
  volume={21},
  pages={1393-1409}
}
Pluripotency, the ability of a cell to differentiate and give rise to all embryonic lineages, defines a small number of mammalian cell types such as embryonic stem (ES) cells. While it has been generally held that pluripotency is the product of a transcriptional regulatory network that activates and maintains the expression of key stem cell genes, accumulating evidence is pointing to a critical role for epigenetic processes in establishing and safeguarding the pluripotency of ES cells, as well… CONTINUE READING
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