Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome.

@article{Ramasubramanyan2012DynamicCE,
  title={Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome.},
  author={Sharada Ramasubramanyan and Kay Osborn and Kirsty Flower and Alison J. Sinclair},
  journal={Journal of virology},
  year={2012},
  volume={86 3},
  pages={1809-19}
}
The ability of Epstein-Barr virus (EBV) to establish latency allows it to evade the immune system and to persist for the lifetime of its host; one distinguishing characteristic is the lack of transcription of the majority of viral genes. Entry into the lytic cycle is coordinated by the viral transcription factor, Zta (BZLF1, ZEBRA, and EB1), and downstream effectors, while viral genome replication requires the concerted action of Zta and six other viral proteins at the origins of lytic… CONTINUE READING