Dynamic changes of matrix metalloproteinases and their tissue inhibitors in severe sepsis.

@article{Mhl2011DynamicCO,
  title={Dynamic changes of matrix metalloproteinases and their tissue inhibitors in severe sepsis.},
  author={Di{\'a}na M{\"u}hl and B{\'a}lint Nagy and G{\'a}bor L{\'a}szl{\'o} Woth and Bogl{\'a}rka Falusi and Lajos Bog{\'a}r and Gy{\"o}rgy W{\'e}ber and J{\'a}nos Lantos},
  journal={Journal of critical care},
  year={2011},
  volume={26 6},
  pages={550-5}
}
PURPOSE Little is known about the dynamic changes of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in sepsis. Our aim was therefore to investigate the time course of MMPs and their inhibitors in patients experiencing severe sepsis. METHODS Our prospective controlled analysis included 38 patients with severe sepsis. Plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured daily at a 5-day-long period with enzyme-linked immunosorbent assay. Seventeen healthy volunteers… CONTINUE READING