Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy.

  title={Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy.},
  author={Saumya G Sharma and Heinrich Taegtmeyer and Julia V. Adrogue and Peter Razeghi and Shiraj Sen and Kholiswa C. Ngumbela and M Faadiel Essop},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={286 3},
Hypobaric hypoxia induces right ventricular hypertrophy. The relative contribution of pulmonary hypertension, decreased arterial oxygen, and neuroendocrine stimulation to the transcriptional profile of hypoxia-induced right ventricular hypertrophy is unknown. Whereas both ventricles are exposed to hypoxia and neuroendocrine stimulation, only the right ventricle is exposed to increased load. We postulated that right ventricular hypertrophy would reactivate the fetal gene transcriptional profile… CONTINUE READING


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