Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories

@inproceedings{Pattwell2016DynamicCI,
  title={Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories},
  author={Siobhan S. Pattwell and Conor Liston and Deqiang Q Jing and Ipe Ninan and Rui R. Yang and Jonathan Witztum and Mitchell H. Murdock and Iva Dincheva and Kevin G. Bath and Betty Jo Casey and Karl Deisseroth and Francis B. S. Lee},
  booktitle={Nature communications},
  year={2016}
}
Fear can be highly adaptive in promoting survival, yet it can also be detrimental when it persists long after a threat has passed. Flexibility of the fear response may be most advantageous during adolescence when animals are prone to explore novel, potentially threatening environments. Two opposing adolescent fear-related behaviours-diminished extinction of cued fear and suppressed expression of contextual fear-may serve this purpose, but the neural basis underlying these changes is unknown… CONTINUE READING
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