Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.

@article{Akar2007DynamicCI,
  title={Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.},
  author={Fadi Gabriel Akar and Robert Daniel Nass and Samuel Hahn and Eugenio Cingolani and Manish Shah and Geoffrey G. Hesketh and Deborah Disilvestre and Richard S. Tunin and David A. Kass and Gordon F. Tomaselli},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 2},
  pages={H1223-30}
}
End-stage heart failure (HF) is characterized by changes in conduction velocity (CV) that predispose to arrhythmias. Here, we investigate the time course of conduction changes with respect to alterations in connexin 43 (Cx43) properties and mechanical function during the development of HF. We perform high-resolution optical mapping in arterially perfused myocardial preparations from dogs subjected to 0, 3, 7, 14, and 21 days of rapid pacing to produce variable degrees of remodeling. CV is… CONTINUE READING
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