Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis

@inproceedings{Schaefer2010DynamicCI,
  title={Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis},
  author={Jochen T Schaefer and James W. Patterson and Donna H. Deacon and Mark Smolkin and Gina R. Petroni and Emily M Jackson and Craig L Slingluff},
  booktitle={Journal of Translational Medicine},
  year={2010}
}
Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular effects in human skin. We hypothesized that a vaccine in incomplete Freund's adjuvant (IFA) would increase dermal Th1 and Tc1-lymphocytes and mature DCs, but that repeated vaccination may increase regulatory cells. During and after 6 weekly immunizations with a multipeptide vaccine… CONTINUE READING

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