Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation.

  title={Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation.},
  author={Stefan Fischer and Alexandra A Maclean and Mingyao Liu and Jonathan A Cardella and Arthur S Slutsky and Michiharu Suga and Jos{\'e} Cl{\'a}udio Fonseca Moreira and Shaf H Keshavjee},
  journal={American journal of respiratory and critical care medicine},
  volume={162 5},
Ischemia-reperfusion (IR) injury is a major cause of organ dysfunction following lung transplantation. We have recently described increased apoptosis in transplanted human lungs after graft reperfusion. However, a direct correlation between ischemic time, cell death, and posttransplant lung function has not yet been demonstrated. We hypothesized that an increased ischemic period would lead to an increase in cell death, and that the degree and type of cell death would correlate with lung… CONTINUE READING


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