Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation.

@article{OwessonWhite2008DynamicCI,
  title={Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation.},
  author={Catarina A Owesson-White and Joseph F. Cheer and Manna Beyene and Regina M Carelli and R Mark Wightman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 33},
  pages={11957-62}
}
Dopamine in the nucleus accumbens (NAc) is an important neurotransmitter for reward-seeking behaviors such as intracranial self-stimulation (ICSS), although its precise role remains unclear. Here, dynamic fluctuations in extracellular dopamine were measured during ICSS in the rat NAc shell with fast-scan cyclic voltammetry at carbon-fiber microelectrodes. Rats were trained to press a lever to deliver electrical stimulation to the substantia nigra (SNc)/ventral tegmental area (VTA) after the… CONTINUE READING
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