Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived neurotrophic factor promoter.

@article{Yossifoff2008DynamicCI,
  title={Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived neurotrophic factor promoter.},
  author={Maya Yossifoff and Tatiana Kisliouk and Noam Meiri},
  journal={The European journal of neuroscience},
  year={2008},
  volume={28 11},
  pages={
          2267-77
        }
}
Thermal control establishment develops during a critical period by alterations in cellular properties in the frontal hypothalamus. These alterations may be modulated by the epigenetic code that determines the repertoire of transcribed proteins. Here we demonstrate transient changes in the expression of brain-derived neurotrophic factor (Bdnf) during both thermal conditioning and re-exposure of conditioned chicks to heat stress, relative to their age-matched naive counterparts. These changes… CONTINUE READING
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