Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.

@article{Kim2014DynamicCI,
  title={Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.},
  author={Mirang Kim and Young-Kyu Park and Tae-Wook Kang and Sang-Hun Lee and Yong‐Hee Rhee and Jong-Lyul Park and Hee-Jin Kim and Daeyoup Lee and Doheon Lee and Seon-Young Kim and Yong Sung Kim},
  journal={Human molecular genetics},
  year={2014},
  volume={23 3},
  pages={
          657-67
        }
}
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge is limited about the genome-wide distribution of 5-methylcytosine (5 mC) and 5-hydroxymethylcytosine (5 hmC) during cellular differentiation. Using an in vitro model system of gradual differentiation of human embryonic stem (hES) cells into ventral midbrain-type neural precursor cells and terminally into dopamine neurons, we observed dramatic genome-wide changes in 5 mC and 5… 
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