Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.

@article{Kim2014DynamicCI,
  title={Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.},
  author={Mirang Kim and Young-Kyu Park and Tae-Wook Kang and Sang-Hun Lee and Yong-Hee Rhee and Jong-lyul Park and Hee-Jin Kim and Daeyoup Lee and Doheon Lee and Seon-Young Kim and Yong Sung Kim},
  journal={Human molecular genetics},
  year={2014},
  volume={23 3},
  pages={
          657-67
        }
}
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge is limited about the genome-wide distribution of 5-methylcytosine (5 mC) and 5-hydroxymethylcytosine (5 hmC) during cellular differentiation. Using an in vitro model system of gradual differentiation of human embryonic stem (hES) cells into ventral midbrain-type neural precursor cells and terminally into dopamine neurons, we observed dramatic genome-wide changes in 5 mC and 5… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Identification of DNA methylation markers for lineage commitment of in vitro hepatogenesis.

Mirang Kim, Tae-Wook Kang, +7 authors Yong Sung Kim
  • Human molecular genetics
  • 2011
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

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