Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke

@article{Guo2016DynamicCO,
  title={Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke},
  author={Zhiliang Guo and Shuhong Yu and Lu-lu Xiao and X. Chen and R. Ye and Ping Zheng and Q. Dai and Wen Sun and C. Zhou and Shui-ping Wang and Wusheng Zhu and Xinfeng Liu},
  journal={Journal of Neuroinflammation},
  year={2016},
  volume={13}
}
BackgroundThe neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complications after thrombolysis.MethodsA total of 189 ischemic stroke patients were prospectively enrolled. Blood samples for leukocyte, neutrophil, and lymphocyte counts were obtained at… Expand
High Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
TLDR
High NLR could be a useful marker for predicting HT in AIS patients after IVT, and univariate analysis indicated that patients with HT had higher NIHSS scores than other patients with AIS treated with IVT. Expand
Dynamic increase in neutrophil levels predicts parenchymal hemorrhage and function outcome of ischemic stroke with r-tPA thrombolysis
  • Anna Ying, YaNi Cheng, YanYan Lin, JunRu Yu, XiaoYun Wu, YuanShao Lin
  • Medicine
  • Neurological Sciences
  • 2020
TLDR
Dynamic increase in neutrophil and NLR after stroke may predict parenchymal hemorrhage and 3-month poor outcome in AIS patients receiving r-tPA treatment. Expand
Neutrophil to lymphocyte ratio predicts intracranial hemorrhage after endovascular thrombectomy in acute ischemic stroke
TLDR
NLR is an independent predictor for the development of ICH after EVT and further studies are needed to investigate the role of the immune system in hemorrhagic complications following EVT, and confirm the value of NLR as a potential biomarker. Expand
Neutrophil-to-Lymphocyte Ratio and Symptomatic Hemorrhagic Transformation in Ischemic Stroke Patients Undergoing Revascularization
TLDR
NLR at admission can accurately predict Symptomatic hemorrhagic transformation in patients with AIS undergoing revascularization, and showed good discriminatory power. Expand
Neutrophil-to-lymphocyte Ratio as a Risk Determinant of Hemorrhage Transformation in Acute Ischemic Stroke
TLDR
Investigation of the clinical significance between neutrophil-to-lymphocyte ratio (NLR) and classification of non-thrombolytic hemorrhagic transformation (HT) in acute ischemic stroke (AIS) found NLR values were significantly increased and correlated with bothHI and PH groups and NLR could be used as a predictor of both HI and PH. Expand
Predictive value of admission neutrophil/lymphocyte ratio in symptomatic intracranial hemorrhage after stroke thrombolysis
TLDR
Whether the baseline neutrophil/lymphocyte ratio (NLR) predicts symptomatic intracranial hemorrhage (SICH) due to intravenous thrombolytic therapy is determined and a precise cut-off value could not be found to predict the hemorrhagic transformation. Expand
Neutrophil-Lymphocyte Ratio Predicts Functional and Safety Outcomes after Endovascular Treatment for Acute Ischemic Stroke
TLDR
NLR independently predicts 3-month functional outcome and sICH but the existence of a trend association with mortality after EVT for acute anterior circulation LVOS patients is not found. Expand
Admission Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker of Outcomes in Large Vessel Occlusion Strokes
TLDR
Higher admission NLR is an independent predictor of symptomatic intracranial hemorrhage and 3-month mortality in large vessel occlusion patients treated with mechanical thrombectomy, and it may identify a target group for testing adjunctive anti-inflammatory therapies. Expand
Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
TLDR
Although there are some deficits in this study, it may be feasible to predict the prognosis of reperfusion therapy in AIS patients with NLR levels, and increasedNLR levels are positively associated with greater risk of sICH, 3-month poor functional outcome and 3- month mortality in A IS patients undergoing reperfusions treatments. Expand
Neutrophil to lymphocyte ratio predicts poor outcomes after acute ischemic stroke: A cohort study and systematic review
TLDR
Higher NLR is positively associated with the risk of HT and 3-month death after stroke and more studies should validate the role of NLR in prognostic models. Expand
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