Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34+, CD34+CD38- and early lymphoid CD7+ cells.

@article{Silva2010DynamicCI,
  title={Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34+, CD34+CD38- and early lymphoid CD7+ cells.},
  author={Cl{\'a}udia L da Silva and Raquel Gonçalves and Francisco F dos Santos and Pedro Z. Andrade and Graça Almeida-Porada and Joaquim M S Cabral},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2010},
  volume={4 2},
  pages={149-58}
}
Most clinical applications of haematopoietic stem/progenitor cells (HSCs) would benefit from their ex vivo expansion to obtain a therapeutically significant amount of cells from the available donor samples. We studied the impact of cellular interactions between umbilical cord blood (UCB) haematopoietic cells and bone marrow (BM)-derived mesenchymal stem cells (MSCs) on the ex vivo expansion and differentiative potential of UCB CD34(+)-enriched cells. UCB cells were cultured: (a) directly in… CONTINUE READING
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