Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.

@article{Byun2009DynamicBO,
  title={Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.},
  author={Jung Soo Byun and Madeline M. Wong and Wenwu Cui and Gila Idelman and Quentin Li and Adriana De Siervi and Sven Bilke and Cynthia M. Haggerty and Audrey Player and Yong Wang and Michael J. Thirman and Joseph J. Kaberlein and Constantinos Petrovas and Richard A. Koup and Dan L. Longo and Keiko Ozato and Kevin Gardner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 46},
  pages={
          19286-91
        }
}
Profiling the dynamic interaction of p300 with proximal promoters of human T cells identified a class of genes that rapidly coassemble p300 and RNA polymerase II (pol II) following mitogen stimulation. Several of these p300 targets are immediate early genes, including FOS, implicating a prominent role for p300 in the control of primary genetic responses. The recruitment of p300 and pol II rapidly transitions to the assembly of several elongation factors, including the positive transcriptional… CONTINUE READING

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