Dynamic balance of segregation distortion and selection maintains normal allele sizes at the myotonic dystrophy locus.

@article{Polaski1998DynamicBO,
  title={Dynamic balance of segregation distortion and selection maintains normal allele sizes at the myotonic dystrophy locus.},
  author={Andrzej Polański and R. Murgai S. Chakraborty and Marek Kimmel and Ranjan Deka},
  journal={Mathematical biosciences},
  year={1998},
  volume={147 1},
  pages={93-112}
}
Myotonic dystrophy (DM), an autosomal dominant neurological disorder, is caused by CTG-repeat expansions at the DMPK locus, with affected individuals having > or = 50 repeats of this trinucleotide. Reduced reproductive fitness of affected individuals and decreased viability of congenital DM have been noted. Expanded CTG-repeat alleles are highly unstable… CONTINUE READING