Dynamic aspects of presynaptic calcium currents mediating synaptic transmission.

@article{Takahashi2005DynamicAO,
  title={Dynamic aspects of presynaptic calcium currents mediating synaptic transmission.},
  author={Tomoyuki Takahashi},
  journal={Cell calcium},
  year={2005},
  volume={37 5},
  pages={
          507-11
        }
}
Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function. 
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