Dynamic aspects of presynaptic calcium currents mediating synaptic transmission.

@article{Takahashi2005DynamicAO,
  title={Dynamic aspects of presynaptic calcium currents mediating synaptic transmission.},
  author={Tomoyuki Takahashi},
  journal={Cell calcium},
  year={2005},
  volume={37 5},
  pages={507-11}
}
Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function. 

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…