Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4.

@article{Toda2012DynamicAO,
  title={Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4.},
  author={Teppei Toda and Kazuhiko Kuwahara and Naoyuki Kondo and Zene Matsuda and Yosuke Maeda and Kazuhiko Maeda and Nobuo Dr Sakaguchi},
  journal={Immunobiology},
  year={2012},
  volume={217 9},
  pages={
          864-72
        }
}
HIV-1 entry into cells is mediated by interactions between the envelope (Env) gp120 and gp41 proteins with CD4 and chemokine receptors via an intermediate called the viral fusion complex (vFC). Here, mAbs were used to find the dynamic changes in expression of antigenic epitopes during vFC formation. A CD4-specific mAb (R275) and anti-vFC mAbs, designated F12-1, F13-6 and F18-4 that recognize the epitopes only appeared by the co-culture of env-transfected 293FT and CD4-transfected 293 cells… CONTINUE READING
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