Dynamic antibody responses to the Mycobacterium tuberculosis proteome.

@article{KunnathVelayudhan2010DynamicAR,
  title={Dynamic antibody responses to the Mycobacterium tuberculosis proteome.},
  author={Shajo Kunnath-Velayudhan and Hugh Salamon and Hui-Yun Wang and Amy Davidow and Douglas M. Molina and Vu T Huynh and Daniela M Cirillo and Gerd Michel and Elizabeth A. Talbot and Mark D. Perkins and Philip L. Felgner and Xiaowu Liang and Maria Laura Gennaro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 33},
  pages={14703-8}
}
Considerable effort has been directed toward controlling tuberculosis, which kills almost two million people yearly. High on the research agenda is the discovery of biomarkers of active tuberculosis (TB) for diagnosis and for monitoring treatment outcome. Rational biomarker discovery requires understanding host-pathogen interactions leading to biomarker expression. Here we report a systems immunology approach integrating clinical data and bacterial metabolic and regulatory information with high… CONTINUE READING

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