Dynamic and reversible restructuring of the ER induced by PDMP in cultured cells.

@article{Sprocati2006DynamicAR,
  title={Dynamic and reversible restructuring of the ER induced by PDMP in cultured cells.},
  author={Teresa Sprocati and Paolo Ronchi and Andrea Raimondi and Maura Francolini and Nica Borgese},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 15},
  pages={3249-60}
}
In many cells, the endoplasmic reticulum (ER) contains segregated smooth and rough domains, but the mechanism of this segregation is unclear. Here, we used a HeLa cell line, inducibly expressing a GFP fusion protein [GFP-b(5)tail] anchored to the ER membrane, as a tool to investigate factors influencing ER organisation. Induction of GFP-b(5)tail expression caused proliferation of the ER, but its normal branching polygonal meshwork architecture was maintained. Experiments designed to test the… CONTINUE READING
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