Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform.

@article{Taylor2009DynamicAO,
  title={Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform.},
  author={Ronald J. Taylor and Didier Falconnet and Antti Niemist{\"o} and Stephen A. Ramsey and Susanne Prinz and Ilya Shmulevich and Timothy Galitski and Carl L. Hansen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 10},
  pages={3758-63}
}
Cells have evolved biomolecular networks that process and respond to changing chemical environments. Understanding how complex protein interactions give rise to emergent network properties requires time-resolved analysis of cellular response under a large number of genetic perturbations and chemical environments. To date, the lack of technologies for scalable cell analysis under well-controlled and time-varying conditions has made such global studies either impossible or impractical. To address… CONTINUE READING

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