Dynamic allostery governs cyclophilin A-HIV capsid interplay.

@article{Lu2015DynamicAG,
  title={Dynamic allostery governs cyclophilin A-HIV capsid interplay.},
  author={Manman Lu and Guangjin Hou and Hui-Lan Zhang and Christopher L. Suiter and Jinwoo Ahn and In-Ja L Byeon and Juan R. Perilla and Christopher James Langmead and Ivan Fan-Ngai Hung and Peter L. Gor'kov and Zhehong Gan and William W. Brey and Christopher Aiken and Peijun Zhang and Klaus Schulten and Angela M. Gronenborn and Tatyana Polenova},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 47},
  pages={
          14617-22
        }
}
Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of conformational dynamics on the nanosecond to millisecond timescale in HIV-1 CA assemblies in the escape from CypA dependence, by magic-angle spinning (MAS) NMR and molecular dynamics (MD). Through… CONTINUE READING
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