Dynamic allostery governs cyclophilin A–HIV capsid interplay

  title={Dynamic allostery governs cyclophilin A–HIV capsid interplay},
  author={Manman Lu and Guangjin Hou and Hui-lan Zhang and Christopher L. Suiter and J. Ahn and I. Byeon and J. R. Perilla and C. Langmead and I. Hung and P. Gor’kov and Z. Gan and W. Brey and C. Aiken and P. Zhang and K. Schulten and A. Gronenborn and T. Polenova},
  journal={Proceedings of the National Academy of Sciences},
  pages={14617 - 14622}
  • Manman Lu, Guangjin Hou, +14 authors T. Polenova
  • Published 2015
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance The mechanisms of how Cyclophilin A (CypA) regulates HIV-1 infectivity remain poorly understood. We examined the role of dynamics in capsid (CA) protein assemblies by magic-angle-spinning NMR. The assembled CA is highly dynamic. Dipolar tensors calculated from molecular dynamics trajectories are in quantitative agreement with the NMR results. Motions in the CypA loop are sequence-dependent and attenuated in the escape mutants A92E and G94D. Dynamics are similar in escape mutants… CONTINUE READING
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