Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.

@article{Liu2005DynamicAO,
  title={Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.},
  author={Susana Liu and Alain Veilleux and Lei Zhang and A. Dorothy Young and Evonne Kwok and France Lalibert{\'e} and Christine L Chung and Michael R. Tota and Daniel Dub{\'e} and Richard William Friesen and Zheng Huang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={314 2},
  pages={
          846-54
        }
}
The diseases of cystic fibrosis, chronic obstructive pulmonary disease (COPD), and chronic bronchitis are characterized by mucus-congested and inflamed airways. Anti-inflammatory agents that can simultaneously restore or enhance mucociliary clearance through cystic fibrosis transmembrane conductance regulator (CFTR) activation may represent new therapeutics in their treatment. Herein, we report the activation of CFTR-mediated chloride secretion by phosphodiesterase (PDE) 4 inhibitors in T84… CONTINUE READING

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