Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane

@inproceedings{Gokhin2015DynamicAF,
  title={Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane},
  author={David S. Gokhin and Roberta B. Nowak and Joseph A. Khoory and Alfonso de la Piedra and Ionita Ghiran and Velia M Fowler},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Short, uniform-length actin filaments function as structural nodes in the spectrin-actin membrane skeleton to optimize the biomechanical properties of red blood cells (RBCs). Despite the widespread assumption that RBC actin filaments are not dynamic (i.e., do not exchange subunits with G-actin in the cytosol), this assumption has never been rigorously tested. Here we show that a subpopulation of human RBC actin filaments is indeed dynamic, based on rhodamine-actin incorporation into filaments… CONTINUE READING
2
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4

  • Molecular biology of the cell
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

The neuronal and actin commitment: Why do neurons need rings?

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Actin Assemblies in the Axon Shaft – some Open Questions

  • Current Opinion in Neurobiology
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

Creep and stress relaxation of human red cell membrane

  • Biomechanics and modeling in mechanobiology
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

Structural and dynamic states of actin in the erythrocyte

Jc Pinder, Wb Gratzer
  • 1983
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Jasplakinolide: an actin-specific reagent that promotes actin polymerization.

  • Methods in molecular biology
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Molecular mechanisms controlling actin filament dynamics in nonmuscle cells.

  • Annual review of biophysics and biomolecular structure
  • 2000
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL