Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.

  title={Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.},
  author={Christian A. J. Schulze – Bauer and Edward Yc Kim and Francesco Marangoni and Esteban Carrizosa and Natalie M. Claudio and Thorsten R Mempel},
  journal={The Journal of clinical investigation},
  volume={124 6},
Tregs control various functions of effector T cells; however, where and how Tregs exert their immunomodulatory effects remain poorly understood. Here we developed a murine model of adoptive T cell therapy and found that Tregs induce a dysfunctional state in tumor-infiltrating CTLs that resembles T cell exhaustion and is characterized by low expression of effector cytokines, inefficient cytotoxic granule release, and coexpression of coinhibitory receptors PD-1 and TIM-3. Induction of CTL… CONTINUE READING
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