Dynamic Transcription Factor Networks in Epithelial-Mesenchymal Transition in Breast Cancer Models

@inproceedings{Siletz2013DynamicTF,
  title={Dynamic Transcription Factor Networks in Epithelial-Mesenchymal Transition in Breast Cancer Models},
  author={Anaar E Siletz and Michael Schnabel and Ekaterina Kniazeva and Andrew J. Schumacher and Seungjin Shin and Jacqueline Sara Jeruss and Lonnie D Shea},
  booktitle={PloS one},
  year={2013}
}
The epithelial-mesenchymal transition (EMT) is a complex change in cell differentiation that allows breast carcinoma cells to acquire invasive properties. EMT involves a cascade of regulatory changes that destabilize the epithelial phenotype and allow mesenchymal features to manifest. As transcription factors (TFs) are upstream effectors of the genome-wide expression changes that result in phenotypic change, understanding the sequential changes in TF activity during EMT provides rich… CONTINUE READING

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