Dynamic Regulation of Oct1 during Mitosis by Phosphorylation and Ubiquitination

  title={Dynamic Regulation of Oct1 during Mitosis by Phosphorylation and Ubiquitination},
  author={Jinsuk Kang and B. Goodman and Y. Zheng and D. Tantin},
  journal={PLoS ONE},
  • Jinsuk Kang, B. Goodman, +1 author D. Tantin
  • Published 2011
  • Biology, Medicine
  • PLoS ONE
  • Background Transcription factor Oct1 regulates multiple cellular processes. It is known to be phosphorylated during the cell cycle and by stress, however the upstream kinases and downstream consequences are not well understood. One of these modified forms, phosphorylated at S335, lacks the ability to bind DNA. Other modification states besides phosphorylation have not been described. Methodology/Principal Findings We show that Oct1 is phosphorylated at S335 in the Oct1 DNA binding domain during… CONTINUE READING
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