Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

@article{Spruijt2013DynamicRF,
  title={Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives},
  author={Cornelia G. Spruijt and Felix A Gnerlich and Arne H Smits and Toni Pfaffeneder and Pascal W.T.C. Jansen and Christina Bauer and Martin Muenzel and Mirko Wagner and Markus M{\"u}ller and Fariha Khan and H. Christian Eberl and Anneloes Mensinga and Arie B Brinkman and Konstantin Lephikov and Udo M{\"u}ller and J{\"o}rn Walter and Rolf Boelens and Hugo van Ingen and Heinrich Leonhardt and Thomas Carell and Michiel Vermeulen},
  journal={Cell},
  year={2013},
  volume={152},
  pages={1146-1159}
}
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC), and adult mouse brain tissue. Readers for these modifications are only partially overlapping, and some readers, such as Rfx proteins, display… CONTINUE READING

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