Dynamic Optimization of a Batch Pharmaceutical Reaction using the Design of Dynamic Experiments ( DoDE ) : the Case of an Asymmetric Catalytic Hydrogenation Reaction

Abstract

The present research work aims to demonstrate the effectiveness of the new methodology of Design of Dynamic Experiments (DoDE) in optimizing an important pharmaceutical reaction. An easily developed response surface model (RSM) is used instead of a hard to develop knowledge-driven process model. The DoDE approach allows the experimenter to introduce dynamic… (More)

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