Dynamic Optimization of Bioreactors : a Review

  title={Dynamic Optimization of Bioreactors : a Review},
  author={Julio R. Banga and Eva Balsa-Canto and Carmen G. Moles and Antonio A. Alonso},
SUMMARY Model based optimization can be successfully used to improve the design and operation of bioreactors. In this contribution, we present a review of this area, especially focusing on the dynamic optimization of fed-batch bioreactors, a class of problems which has attracted (and continues to receive) huge attention. Both classical and more novel approaches, like those using bio-inspired optimization methods, are discussed. Finally, future research trends and needs are outlined.