Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells.

@article{Zachara2004DynamicOM,
  title={Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells.},
  author={Natasha Elizabeth Zachara and Niall O'Donnell and Win Den Cheung and Jessica J Mercer and Jamey D Marth and Gerald W. Hart},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 29},
  pages={30133-42}
}
Cellular response to environmental, physiological, or chemical stress is key to survival following injury or disease. Here we describe a unique signaling mechanism by which cells detect and respond to stress in order to survive. A wide variety of stress stimuli rapidly increase nucleocytoplasmic protein modification by O-linked beta-N-acetylglucosamine (O-GlcNAc), an essential post-translational modification of Ser and Thr residues of metazoans. Blocking this post-translational modification, or… CONTINUE READING
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hp://w w w .jb.org/ D

  • K. Barnes, J. C. Ingram, +7 authors S. A. Baldwin
  • J Cell Sci 115,
  • 2002

hp://w w w .jb.org/ D ow nladed from 33 by gest on July 15

  • G. Mer, H. Hietter, J. F. Lefevre
  • Nat Struct Biol
  • 1996
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