Dynamic Mechanisms of Cell Rigidity Sensing: Insights from a Computational Model of Actomyosin Networks

@inproceedings{Borau2012DynamicMO,
  title={Dynamic Mechanisms of Cell Rigidity Sensing: Insights from a Computational Model of Actomyosin Networks},
  author={Carlos Borau and Taeyoon Kim and Tamara Carla Bidone and Jos{\'e} Manuel Garc{\'i}a-Aznar and Roger D Kamm},
  booktitle={PloS one},
  year={2012}
}
Cells modulate themselves in response to the surrounding environment like substrate elasticity, exhibiting structural reorganization driven by the contractility of cytoskeleton. The cytoskeleton is the scaffolding structure of eukaryotic cells, playing a central role in many mechanical and biological functions. It is composed of a network of actins, actin cross-linking proteins (ACPs), and molecular motors. The motors generate contractile forces by sliding couples of actin filaments in a polar… CONTINUE READING