Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations

@inproceedings{Chang2013DynamicLC,
  title={Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations},
  author={Shang-Lin Chang and Huei-Yi Lai and Shu-Yun Tung and J Y Leu},
  booktitle={PLoS genetics},
  year={2013}
}
Large-scale genome rearrangements have been observed in cells adapting to various selective conditions during laboratory evolution experiments. However, it remains unclear whether these types of mutations can be stably maintained in populations and how they impact the evolutionary trajectories. Here we show that chromosomal rearrangements contribute to extremely high copper tolerance in a set of natural yeast strains isolated from Evolution Canyon (EC), Israel. The chromosomal rearrangements in… CONTINUE READING
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