Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine

@article{Kourrich2013DynamicIB,
  title={Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine},
  author={Sa{\"i}d Kourrich and Teruo Hayashi and J F Chuang and Shang-Yi A Tsai and T. -P. Su and Antonello Bonci},
  journal={Cell},
  year={2013},
  volume={152},
  pages={236-247}
}
The sigma-1 receptor (Sig-1R), an endoplasmic reticulum (ER) chaperone protein, is an interorganelle signaling modulator that potentially plays a role in drug-seeking behaviors. However, the brain site of action and underlying cellular mechanisms remain unidentified. We found that cocaine exposure triggers a Sig-1R-dependent upregulation of D-type K(+) current in the nucleus accumbens (NAc) that results in neuronal hypoactivity and thereby enhances behavioral cocaine response. Combining ex vivo… CONTINUE READING

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