Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

@article{Voss2011DynamicEA,
  title={Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism},
  author={Ty C. Voss and R. Louis Schiltz and Myong-Hee Sung and Paul M Yen and John A. Stamatoyannopoulos and Simon C. Biddie and Thomas A. Johnson and Tina Branscombe Miranda and S Rose John and Gordon L. Hager},
  journal={Cell},
  year={2011},
  volume={146},
  pages={544-554}
}
The glucocorticoid receptor (GR), like other eukaryotic transcription factors, regulates gene expression by interacting with chromatinized DNA response elements. Photobleaching experiments in living cells indicate that receptors transiently interact with DNA on the time scale of seconds and predict that the response elements may be sparsely occupied on average. Here, we show that the binding of one receptor at the glucocorticoid response element (GRE) does not reduce the steady-state binding of… CONTINUE READING
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Chromatin accessibility dictates de novo regulatory factor binding

  • S. John, R. E. Thurman, +5 authors J. A. Stamatoyannopoulos
  • Nat. Genet
  • 2011
Highly Influential
10 Excerpts

Transcription dynamics

  • G. L. Hager, J. G. McNally, T. andMisteli
  • Mol . Cell
  • 2009
3 Excerpts

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