Dynamic DNA methylation programs persistent adverse effects of early-life stress

@article{Murgatroyd2009DynamicDM,
  title={Dynamic DNA methylation programs persistent adverse effects of early-life stress},
  author={Christopher Murgatroyd and Alexandre V. Patchev and Yonghe Wu and Vincenzo Micale and Yvonne Bockm{\"u}hl and Dieter Fischer and Florian Holsboer and Carsten T. Wotjak and Osborne F. X. Almeida and Dietmar Spengler},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={1559-1566}
}
Adverse early life events can induce long-lasting changes in physiology and behavior. We found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone and alterations in passive stress coping and memory. This phenotype was accompanied by a persistent increase in arginine vasopressin (AVP) expression in neurons of the hypothalamic paraventricular nucleus and was reversed by an AVP receptor antagonist. Altered Avp expression was associated with sustained DNA… 
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