Dynamic Compression of Chondrocyte-Agarose Constructs Reveals New Candidate Mechanosensitive Genes

@inproceedings{Bougault2012DynamicCO,
  title={Dynamic Compression of Chondrocyte-Agarose Constructs Reveals New Candidate Mechanosensitive Genes},
  author={Carole Bougault and Elisabeth Aubert-Foucher and Anne Sandrine Paumier and Emeline Perrier-Groult and Ludovic Huot and David Hot and Martine Duterque-Coquillaud and Fr{\'e}d{\'e}ric Mall{\'e}in-G{\'e}rin},
  booktitle={PloS one},
  year={2012}
}
Articular cartilage is physiologically exposed to repeated loads. The mechanical properties of cartilage are due to its extracellular matrix, and homeostasis is maintained by the sole cell type found in cartilage, the chondrocyte. Although mechanical forces clearly control the functions of articular chondrocytes, the biochemical pathways that mediate cellular responses to mechanical stress have not been fully characterised. The aim of our study was to examine early molecular events triggered by… CONTINUE READING
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