Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

@article{Scully1997DynamicCO,
  title={Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage},
  author={Ralph Scully and Junjie Chen and Robert L. Ochs and Kathleen Keegan and Merl F. Hoekstra and J. Le Feunteun and David Livingston},
  journal={Cell},
  year={1997},
  volume={90},
  pages={425-435}
}
BRCA1 localizes to discrete nuclear foci (dots) during S phase. Hydroxyurea-mediated DNA synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures. Ultraviolet light, mitomycin C, or gamma irradiation produced a similar effect but with no concurrent arrest of DNA synthesis. BARD1 and Rad51, two proteins associated with the BRCA1 dots, behaved similarly. Loss of the BRCA1 foci was accompanied by a specific, dose-dependent change(s) in the state of BRCA1 phosphorylation… CONTINUE READING
BETA

Similar Papers

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 331 CITATIONS, ESTIMATED 74% COVERAGE

Multi-step process of human breast carcinogenesis: a role for BRCA1, BECN1, CCND1, PTEN and UVRAG.

  • Molecular medicine reports
  • 2011
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

  • Current Biology
  • 2000
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

  • Genes & development
  • 2000
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

  • Cancer research
  • 2000
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing

  • Journal of Cancer
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1998
2018

CITATION STATISTICS

  • 45 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

BRCA1 is a component of the RNA polymerase II holoenzyme.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Location of BRCA 1 in human breast and ovarian cell lines

R. Scully, S. Ganesan, M. Brown, J. A. De Caprio, S. A. Cannistra
  • Science
  • 1996
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

A strong candidate for the breast and ovarian cancer phys

Y. Miki, J. Swensen, D. Shattuck-Eidens, P. A. Futreal
  • Acta Science
  • 1994
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

BRCA1 mutations in primary breast and ovarian gene MEC1

P. A. Futreal, Q. Liu, D. Shattuck-Eidens, C. Cochran, K Harshmann
  • Cell
  • 1994
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1997

BRCA1 is a cell cycle-regulated nuclear phosphoprotein.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 1 EXCERPT

From BRCA 1 to RAP 1 : a kinase from a radiosensitive human cell line

J. P. Mornon
  • Science
  • 1997
VIEW 1 EXCERPT