Dynamic Changes in Normal Liver Parenchymal Volume During Chemotherapy for Colorectal Cancer: Liver Atrophy as an Alternate Marker of Chemotherapy-Associated Liver Injury

@article{Shindoh2019DynamicCI,
  title={Dynamic Changes in Normal Liver Parenchymal Volume During Chemotherapy for Colorectal Cancer: Liver Atrophy as an Alternate Marker of Chemotherapy-Associated Liver Injury},
  author={J. Shindoh and Yuta Kobayashi and K. Kinowaki and Y. Mise and W. Gonoi and S. Yoshida and K. Tani and S. Matoba and H. Kuroyanagi and M. Hashimoto},
  journal={Annals of Surgical Oncology},
  year={2019},
  volume={26},
  pages={4100 - 4107}
}
The purpose of this study was to investigate the incidence, origin, and clinical significance of liver atrophy during chemotherapy for colorectal cancer. This study included 103 patients who underwent chemotherapy before resection for colorectal liver metastases (training set) and 171 patients who underwent adjuvant or first-line chemotherapy without liver resection (validation set). A greater than 10% decrease (atrophy) or increase (hypertrophy) of the liver volume from the baseline was… Expand

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