Dynamic Ca2+-induced inward rectification of K+ current during the ventricular action potential.

@article{Zaza1998DynamicCI,
  title={Dynamic Ca2+-induced inward rectification of K+ current during the ventricular action potential.},
  author={Antonio Zaza and M. S. R. Rocchetti and Angelica Brioschi and Annalisa Cantadori and Arnaldo Ferroni},
  journal={Circulation research},
  year={1998},
  volume={82 9},
  pages={947-56}
}
Inward rectification, an important determinant of cell excitability, can result from channel blockade by intracellular cations, including Ca2+. However, mostly on the basis of indirect arguments, Ca2+-mediated rectification of inward rectifier K+ current (IK1) is claimed to play no role in the mammalian heart. The present study investigates Ca2+-mediated… CONTINUE READING