Dynamic Bioreactor Culture of High Volume Engineered Bone Tissue.

  title={Dynamic Bioreactor Culture of High Volume Engineered Bone Tissue.},
  author={Bao-Ngoc B. Nguyen and Henry Ko and Rebecca A Moriarty and Julie M Etheridge and John P. Fisher},
  journal={Tissue engineering. Part A},
  volume={22 3-4},
Within the field of tissue engineering and regenerative medicine, the fabrication of tissue grafts of any significant size--much less a whole organ or tissue--remains a major challenge. Currently, tissue-engineered constructs cultured in vitro have been restrained in size primarily due to the diffusion limit of oxygen and nutrients to the center of these grafts. Previously, we developed a novel tubular perfusion system (TPS) bioreactor, which allows the dynamic culture of bead-encapsulated… CONTINUE READING
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