Dynamic Binding Mode of a Synaptotagmin-1-SNARE Complex in Solution

Rapid neurotransmitter release depends on the Ca2+ sensor Synaptotagmin-1 (Syt1) and the SNARE complex formed by synaptobrevin, syntaxin-1 and SNAP-25. How Syt1 triggers release has been unclear, partly because elucidating high-resolution structures of Syt1–SNARE complexes has been challenging. An NMR approach based on lanthanide-induced pseudocontact… (More)