Dynamic Agent-Based Model of Hand-Preference Behavior Patterns in the Mouse

  title={Dynamic Agent-Based Model of Hand-Preference Behavior Patterns in the Mouse},
  author={A. Ribeiro and J. Lloyd-Price and B. Eales and F. Biddle},
  journal={Adaptive Behavior},
  pages={116 - 131}
Using a new agent-based model that mimics the learning process in hand-reaching behavior of individual mice, we show that mouse hand preference is probabilistic, dependent on the environment and prior learning. We quantify the learning capabilities of three inbred strains and show that population distributions of hand preference emerge from the properties of individual mice. The model informs our understanding of gene—environment interactions because it accommodates genotypic differences in… Expand
Biological Limits of Hand Preference Learning Hiding Behind the Genes
This chapter describes hand-reaching behavior of mice and the discovery that it is a complex adaptive behavior in which future preference is genotypically dependent on past experience and defines the key elements that led to the collaborative development of a stochastic agent-based model. Expand
Learning of paw preference in mice is strain dependent, gradual and based on short-term memory of previous reaches
We studied the dynamics of paw preference learning in unbiased symmetrical test chambers where mice, Mus musculus, could freely choose which paw to use. When compared to nonlearner model mice, threeExpand
Predictability and randomness of paw choices are critical elements in the behavioural plasticity of mouse paw preference
Lateralized paw usage of mice, Mus musculus, is a learned behaviour, based on a gradual reinforcement of randomly occurring weak asymmetries in paw choice early in training. The reinforcement reliesExpand
Short-term and long-term memory deficits in handedness learning in mice with absent corpus callosum and reduced hippocampal commissure
Positive autocorrelation between successive paw choices during each session and change in paw-preference bias between sessions indicate that 9XCA mice have weak, but not null, learning skills. Expand
Title: Short-term and Long-term Memory Deficits in Handedness Learning in Mice with absent Corpus Callosum and Reduced Hippocampal Commissure Short Title: Handedness Learning in Mice with absent Cc/hc
The corpus callosum (CC) and hippocampal commissure (HC) are major interhemispheric connections whose role in brain function and behaviors is fascinating and contentious. Paw preference of laboratoryExpand
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Curious chiral cases of caddisfly larvae: handed behavior, asymmetric forms, evolutionary history.
Within one family (Phryganeidae), one or perhaps two species exhibit an excess of sinistral-walled cases, suggesting that genes that bias handed behavior in a particular direction evolved after handed behaviors already existed (genetic assimilation). Expand


Hand-preference training in the mouse reveals key elements of its learning and memory process and resolves the phenotypic complexity in the behaviour.
A detailed kinetic analysis of hand-preference training in the C57BL/6J strain revealed elements of the fundamental process of learning and long-term memory that underlies the behaviour by documenting consolidation of memory, blocking of this consolidation by an inhibitor of protein synthesis, retention of memory and speed of learning in response to training reaches. Expand
Mouse genetic model for left-right hand usage: context, direction, norms of reaction, and memory.
A systematic series of tests of paw usage with naive mice and retests of the individuals in test chambers with the food tube biased to the left or to the right, contrasting the highly lateralized C57BL/6J and the very weakly lateralized (or ambilateral) CDS/Lay inbred strains and their (B6 x CDS) F1 generation resulted in an unexpected qualitative difference in paw usage. Expand
Genetic variation in paw preference (handedness) in the mouse.
There is evidence of significant deviation of the numbers of mice to the left and right of equal paw usage, independent of degree of lateralization, and this suggests that direction of left-right paw usage may be a separate genetic trait in the mouse model. Expand
Lateral asymmetry of paw usage: phenotypic survey of constitutive and experience-conditioned paw-usage behaviours among common strains of the mouse.
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Spatial learning, discrimination learning, paw preference and neocortical ectopias in two autoimmune strains of mice
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A two-locus model for experience-conditioned direction of paw usage in the mouse is suggested by dominant and recessive constitutive paw usage behaviours.
The data suggest a model in which C57BL/6J may have a "strong" allele that identifies a functional difference between the constitutive paw usage of CDS/Lay and DBA/2J, and a model that appears to be dominant to the experience-conditioned behaviour of SWV. Expand
The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes
In the expanded survey, some strains appear to exhibit a directional deviation from equal numbers of mice with left and right paw usage, suggesting direction of paw usage may not be a genetically neutral trait, but replicate assessments and genetic tests are needed to confirm this. Expand
When left-handed mice live in right-handed worlds.
Many C57BL/6J inbred mice were tested for paw preference, and males were more strongly lateralized, and Influences of world bias appear to be superimposed upon an already laterally dichotomized population. Expand
Handedness and laterality in humans and other animals
A survey of the developmental, genetic, paleoneurological, comparative behavior, and neuropsychological evidence indicates that the neural organization responsible for handedness and laterality inExpand
Weak or missing paw lateralization in a mouse strain (I/LnJ) with congenital absence of the corpus callosum
It is concluded that congenital absence of the CC is a factor which may substantially interfere with the development of paw lateralization and depending on age and gender, about half of the acallosal mice develop a paw preference. Expand