Dynactin increases the processivity of the cytoplasmic dynein motor

  title={Dynactin increases the processivity of the cytoplasmic dynein motor},
  author={Stephen J. King and Trina A Schroer},
  journal={Nature Cell Biology},
Cytoplasmic dynein supports long-range intracellular movements of cargo in vivo but does not appear to be a processive motor protein by itself. We show here that the dynein activator, dynactin, binds microtubules and increases the average length of cytoplasmic-dynein-driven movements without affecting the velocity or microtubule-stimulated ATPase kinetics of cytoplasmic dynein. Enhancement of microtubule binding and motility by dynactin are both inhibited by an antibody to dynactin’s… CONTINUE READING
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